Associate Professors
Tan, Haibo
Associate Professor/PI
Post：
Director of Chemical Biology of Plant Resources Lab
Tel：
020-37252958
Add：
No.723, Xingke Road, Tianhe District, Guangzhou
Education：
Ph.D
Email：
tanhaibo@scbg.ac.cn
Zip Code：
510650
Academic Education & Work Career：
Dr. Tan (Haibo Tan) received his B.S. from Huazhong University of Science and Technology in 2009 and Ph.D from Peking University in 2014. He joined the Chemical Biology of Plant Resources Lab, South China Botanical Garden, Chinese Academy of Sciences as an assistant researcher from 2014 to 2016 and then promoted as an associate professor since 2016.
Research Interest：
1. The research of isolation, synthesis, and structure-activity relationship of natural products with biologically significant activities;
2. Bioactive constituents and quality standard of the traditional Chinese medicine;
3. Pharmacological mechanisms of natural products towards the new drug discovery.
Publication：
[1] Zheng, A. Q.; Zhou, T. T.; Wang, S. S.; Zhang, W. G.; Lu, X. X.; Chen, H. Y.*; Tan, H. B.* Total syntheses of hyperaspidinols A and B enabled by a bioinspired diastereoselective cascade sequence. Chin. Chem. Lett. 2022, 33, 885-889.
[2] Liu, H. X.; Liu, Z. M.; Zhang, Y. J.; Chen, Y. C.; Wang, H.; Tan, H. B.*; Zhang, W. M.* Antioxidant aryl-substituted phthalan derivatives produced by endophytic fungus Cytospora rhizophorae. Front. Chem. 2022, 10, 826615.
[3] Zheng, A. Q.; Wang, S. S.; Zhou, T. T.; Chen, Y.; Ke, X.; Chen, H. Y.; Tan, H. B.* Bioinspired syntheses of cryptoflavanones C-D, oboflavanones A-B, and cryptoyunnanones G-H enabled by an acid-triggered cascade sequence. Org. Chem. Front. 2022, 9, 2424-2429.
[4] Zhang, Y. J.#; Liu, H. X.#; Chen, Y. C.; Lu, X. X.; Liu, Z. M.; Tan, H. B.*; Zhang, W. M.* Cyophiobiolins A-D, ophiobolin sestertepenoids from Cytospora rhizophorae. Phytochem. 2022, 195, 113352.
[5] Liu, H. X.; Zhang, Y. J.; Chen, Y. C.; Liu, Z. M.; Tan, H. B.*; Zhang, W. M.* Pyrone and isocoumarin derivatives from the endophytic fungus Cytospora rhizophorae. Org. Biomol. Chem. 2022, 20, 4900-4904.
[6] Zhou, T. T.; Zheng, A. Q.; Zhang, W. G.; Lu, X. X.; Chen, H. Y.*; Tan, H. B.*; Concise total syntheses of two flavans and structure revision assisted by quantum NMR calculations. Org. Biomol. Chem. 2022, 20, 4096-4100.
[7] Xiao, Y. Y.#; Tan, H. B.#; Huang, H. T.; Yu, J. Z.; Zeng, L. T.; Liao, Y. Y.; Wu, P.; Yang, Z. Y.* Light synergistically promotes the tea green leafhopper infestation-induced accumulation of linalool oxides and their glucosides in tea (Camellia sinensis). Food Chem. 2022, 394, 133460.
[8] Yu, Z. H.#; Lu, X. X.#; Choi, J.; Deng, S. L.; Xiong, B. H.; Zhang, W. G.; Wang, H.; Wang, S. S.*; Tan, H. B.* 2-Pyrones from endophytic fungus Diaporthe foeniculina BZM-15. Nat. Prod. Res. 2022, https://doi.org/10.1080/14786419.2021.1904400.
[9] Wu, G. Y.; Zhu, Z. Y.; Zhang, X.; Wang, M. M.; Li, J. X.; Hu, Y. J.*; Tan, H. B.* Chemical constituents from the Streptomyces morookaensis strain Sm4-1986. Nat. Prod. Res. 2022, 36, 3681-3688.
[10] Wang, M. M.; Huo, L. Q.; Liu, H. X.; Zhao, L. Y.; Xu, Z. F.; Tan, H. B.*; Qiu, S. X.* Thujasutchins N-O, two new compounds from the stems and roots of Thuja sutchuenensis. Nat. Prod. Res. 2022, 36, 2356-2362.
[11] Kang, F. X.#; Lu, X. X.#; Zhang, S.; Chen, D. K.; Kuang, M.; Peng, W. W.; Tan, J. B.; Xu, K. P.; Zou, Z. X.*; Tan, H. B.* Diaportones A-C, three new metabolites from endophytic fungus Diaporthe foeniculina BZM-15. Front. Chem. 2021, 755351.
[12] Lu, X. X.; Zhang, Y. J.; Zhang, W. G.; Wang, H.; Zhang, J.; Wang, S. S.*; Tan, H. B.* Cyclohexanone and phenolic acid derivatives from endophytic fungus Diaporthe foeniculina. Front. Chem. 2021, 738307. (*Corresponding author, IF = 5.545)
[13] Liao, Y. Y.#; Tan, H. B.#; Jian, G. X.; Zhou, X. C.; Huo, L. Q.; Jia, Y. X.; Zeng, L. T.; Yang, Z. Y.* Herbivore-induced (Z)-3-hexen-1-ol is an airborne signal that promotes direct and indirect defenses in tea (Camellia sinensis) under light. J. Agric. Food Chem. 2021, 69, 12608-12620.
[14] Zhang, W. G.; Lu, X. X.; Huo, L. Q.; Zhang, S.; Chen, Y.; Zou, Z. X.*; Tan, H. B.* Sesquiterpenes and steroids from an ewndophytic Eutypella scoparia. J. Nat. Prod. 2021, 84, 1715-1724.
[15] Dong, C. M.#; Peng, W. W.#; Wang, H.; Zhang, X.; Zhang, J.; Tan, G. S.; Xu, K. P.*; Zou, Z. X.*; Tan, H. B.* Total syntheses of melodienones by redox isomerization of propargylic alcohols. Org. Biomol. Chem. 2021, 19, 5077-5081.
[16] Zhang, W. G.; Lu, X. X.; Wang, H.; Chen, Y.; Zhang, J.; Zou, Z. X.*; Tan, H. B.* Antibacterial secondary metabolites from the endophytic fungus Eutypella scoparia SCBG-8. Tetrahedron Lett. 2021, 153314.
[17] Wang, S. S.*; Song, M. M.; Li, X. G.; Huang, Y. H.; Zhao, T. X.; Wei, Z. J.; Lan, Y. Y.; Tan, H. B.* Synthesis of heterobiaryl 4-aryl furans through a base-promoted decarboxylative propargylation/cycloisomerization annulation. Org. Lett. 2020, 22, 8752–8757.
[18] Zhang, X.#; Dong, C. M.#; Wu, G. Y.; Huo, L. Q.; Yuan, Y. F.; Hu, Y. J.*; Liu, H. X.*; Tan, H. B.* The biomimetic total syntheses of the antiplasmodial tomentosones A and B. Org. Lett. 2020, 22, 8007-8011.
[19] Huo, L. Q.; Dong, C. M.; Wang, M. M.; Lu, X. X.; Zhang, W. G.; Yang, B.; Yuan, Y. F.; Qiu, S. X.; Liu, H. X.*; Tan, H. B.* Biomimetic total syntheses of sanctis A-B with structure revision. Org. Lett. 2020, 22, 934-938.
[20] Wang, M. M.; Zhao, L. Y.; Chen, K.; Shang, Y. X.; Wu, J. F.; Guo, X. Y.; Chen, Y. H.; Liu, H. X.; Tan, H. B.*; Qiu, S. X.* Antibacterial sesquiterpenes from the stems and roots of Thuja sutchuenensis. Bioorg. Chem. 2020, 96, 103645.
[21] Shi, L. L.#; Wang, S. S.#; Huo, L. Q.; Gao, M. L.; Zhang, W. G.; Lu, X. X.; Qiu, S. X.; Liu, H. X.*; Tan, H. B.*; Diastereoselective construction of the benzannulated spiroketal core of chaetoquadrins enabled by a regiodivergent cascade. Org. Chem. Front. 2020, 7, 2385-2390.
[22] Zhang, X.; Wu, G. Y.; Huo, L. Q.; Guo, X. Y.; Qiu, S. X.; Liu, H. X.*; Tan, H. B.*; Hu, Y. J.* The first racemic total syntheses of the antiplasmodials watsonianones A and B and corymbone B. J. Nat. Prod. 2020, 83, 3-7.
[23] Liu, H. X.#; Chen, Y. C.#; Li, S. N.; Zhang, W. G.; Liu, Z. M.; Tan, H. B.*; Zhang, W. M.* Trichothecene macrolides from the endophytic fungus Paramyrothecium roridum and their cytotoxic activity. Fitoterapia 2020, 147, 104768.
[24] Zhang, W. G., Wang, M. M.; Zhang, S.; Xu, K. P.; Tan, G. S.; Qiu, S. X.; Zou, Z. Z.*; Tan, H. B.* Eutyscoparols A-G, polyketide derivatives from endophytic fungus Eutypella scoparia SCBG-8. Fitoterapia 2020, 146, 104681.
[25] Liu, H. X.#; Chen, S. C.#; Zhang, X.; Dong, C. M.; Chen, Y. C.; Liu, Z. M.; Tan, H. B.*; Zhang, W. M.* Isolation, structural elucidation, total synthesis, and cytotoxic activity of effphenol A. Org. Biomol. Chem. 2020, 18, 9035-9038.
[26] Liu, H. X.#; Tan, H. B.#; Chen, Y. C.; Guo, X. Y.; Wang, W. X.; Guo, H.; Liu, Z. M.; Zhang, W. M.* Cytorhizins A-D, four highly structure-combined benzophenones from the endophytic fungus Cytospora rhizophorae. Org. Lett. 2019, 21, 1063-1067.
[27] Zeng, L. T.#; Tan, H. B.#; Liao, Y. Y.; Jian, G. T.; Kang, M.; Dong, F.; Watanabe, N.; Yang, Z. Y.* Increasing temperature changes flux into multiple biosynthetic pathways for 2-phenylethanol in model systems of tea (Camellia sinensis) and other plants. J. Agr. Food Chem. 2019, 36, 10145-10154.
[28] Liu, H. X.#; Tan, H. B.#; Wang, W. X.; Zhang, W. G.; Chen, Y. C.; Li, S. N.; Liu, Z. M.; Li, H. H.; Zhang, W. M.* Cytorhizophins A and B, benzophenone-hemiterpene adducts from the endophytic fungus Cytospora rhizophorae. Org. Chem. Front. 2019, 6, 591-596.
[29] Zhao, L. Y.; Liu, H. X.; Wang, L.; Xu, Z. F.; Tan, H. B.*; Qiu, S. X.* Rhodomyrtosone B, a membrane-targeting anti-MRSA natural acylphloroglucinol from Rhodomyrtus tomentosa. J. Ethnopharm. 2019, 228, 50-57.
[30] Liu, Z. M.#; Tan, H. B.#; Chen, K.; Chen, Y. C.; Zhang, W. G.; Chen, S. C.; Li, H. H.; Zhang, W. M.* Rhizophols A and B, antioxidant and axially chiral benzophenones from the endophytic fungus: Cytospora rhizophorae. Org. Biomol. Chem. 2019, 17, 10009-10012. (#Contributed equally, IF = 3.890)
[31] Liu, H. X.#; Tan, H. B.#; Chen, K.; Zhao, L. Y.; Chen, Y. C.; Li, S. N.; Li, H. H.; Zhang, W. M.* Cytosporins A-D, novel benzophenone derivatives from the endophytic fungus Cytospora rhizophorae A761. Org. Biomol. Chem. 2019, 17, 2346-2350.
[32] Wu, G. Y.#; Zhang, X.#; Guo, X. Y.; Huo, L. Q.; Liu, H. X.; Shen, X. L.; Qiu, S. X.; Hu, Y. J.*; Tan, H. B.* Prenylated stilbenes and flavonoids from the leaves of Cajanus cajan. Chin. J. Nat. Med. 2019, 5, 381-386.
[33] Li, Y.; Qin, X. B.; Liu, H. X.; Xu, Z. F.; Tan, H. B.*; Qiu, S. X.* Two pairs of enantiomeric propylated flavonoids and a new lignan from the aerial parts of Abrus precatorius. Fitoterapia 2019, 133, 125-129.
[34] Guo, X. Y.; Wang, M. M.; Wu, J. F.; Wu, G. Y.; Zhang, X.; Huo, L. Q.; Liu, H. X.; Chen, Y. H.; Xie, G. W.*; Tan, H. B.*; Qiu, S. X.* Chemical constituents of the trunks and roots of Thuja sutchuenensis. Fitoterapia 2019, 134, 264-269.
[35] Liu, H. X.; Wang, Y.; Guo, X. Y.; Huo, L. Q.; Xu, Z. F.; Zhang, W. M.; Qiu, S. X.; Yang, B.*; Tan, H. B.* A bioinspired cascade sequence enables facile assembly of methanodibenzo[b,f][1,5]dioxocin flavonoid scaffold. Org. Lett. 2018, 20, 546-549.
[36] Shi, L. L.; Liu, H. X.; Huo, L. Q.; Dang, Y. Q.; Wang, Y.; Yang, B.; Qiu, S. X.*; Tan, H. B.* Site-selective phenol acylation mediated by thioacids via visible light photoredox catalysis. Org. Chem. Front. 2018, 5, 1312-1319.
[37] Zhao, L. Y.#; Liu, H. X.#; Huo, L. Q.; Wang, M. M.; Yang, B.; Zhang, W. M.; Xu, Z. F.; Tan, H. B.*; Qiu, S. X.* Structural optimization and antibacterial evaluation of rhodomyrtosone B analogues against MRSA strains. MedChemComm. 2018, 9, 1698-1707.
[38] Yuan, Y.; Wu, J. W.; Li, B. L.; Niu, J.; Tan, H. B.*, Qiu, S. X.* Regulation of signaling pathways involved in the anti-proliferative and apoptosis-inducing effects of M22 against non-small cell lung Adenocarcinoma A549 cells. Sci. Rep. 2018, 8, 992.
[39] Zou, Z. X.; Tan, G. S.; Huang, Q.; Sun, H. H.; Huo, L. Q.; Zhong, W. Q.; Zhao, L. Y.; Liu, H. X.*; Tan, H. B.* Brachyanins A-C, pinene-derived meroterpenoids and phloroglucinol derivative from Leptospermum brachyandrum. Fitoterapia 2018, 130, 184-189.
[40] Liu, H. X.#; Tan, H. B.#; Chen, K.; Chen, Y. C.; Li, S. N.; Li, H. H.; Zhang, W. M.* Cerrenins A-C, cerapicane and isohirsutane sesquiterpenoids from the endophytic fungus Cerrena sp. Fitoterapia 2018, 129, 173-178.
[41] Tan, H. B.#; Liu, H. X.#; Zhao, L. Y.; Yuan, Y.; Li, B. L.; Jiang, Y. M.; Gong, L.*; Qiu, S. X.* Structure-activity relationships and optimization of acyclic acylphloroglucinol analogues as novel antimicrobial agents. Eur. J. Med. Chem. 2017, 125, 492-499.
[42] Liu, H. X.; Huo, L. Q.; Yang, B.; Yuan, Y. F.; Zhang, W. M.; Xu, Z. F.; Qiu, S. X.*; Tan, H. B.* Biomimetic-inspired syntheses of myrtucommuacetalone and myrtucommulone J. Org. Lett. 2017, 19, 4786-4789.
[43] Li, C.; Liu, H. X.; Zhao, L. Y.; Zhang, W. M.; Qiu, S. X.; Yang, X. Y.*; Tan, H. B.* Antibacterial neolignans from the leaves of Melaleuca bracteata. Fitoterapia 2017, 120, 171-176.
[44] Liu, H. X.#; Tan, H. B.#; Liu, Y.; Chen, Y. C.; Li, S. N.; Sun, Z. H.; Li, H. H.; Qiu, S. X.; Zhang, W. M.* Three new highly-oxygenated metabolites from the endophytic fungus Cytospora rhizophorae A761. Fitoterapia 2017, 117, 1-5.
[45] Xiang, Y. Q.; Liu, H. X.; Zhao, L. Y.; Xu, Z. F.; Tan, H. B.*; Qiu, S. X.* Callistemenonone A, a novel dearomatic dibenzofuran-type acylphloroglucinol with antimicrobial activity from Callistemon viminalis. Sci. Rep. 2017, 7, 2363.
[46] Liu, H. X.; Zhao, L. Y.; Yuan, Y. F.; Xu, Z. F.; Chen, K.*; Qiu, S. X.*; Tan, H. B.* Potassium thioacids mediated selective amide and peptide constructions enabled by visible light photoredox catalysis. ACS Catal. 2016, 6, 1732-1736.
[47] Liu, H. X.; Dang, Y. Q.; Yuan, Y. F.; Xu, Z. F.; Qiu, S. X.*; Tan, H. B.* Diacyl disulfide: a reagent for chemoselective acylation of phenols enabled by 4-(N,N-dimethylamino)pyridine catalysis. Org. Lett. 2016, 18, 5584-5587.
[48] Gong, L.#; Tan, H. B.#; Chen, F.; Li, T. T.; Zhu, J. Y.; Jian, Q. J.; Yuan, D. B.; Xu, L. X.; Hu, W. Z.; Jiang, Y. M.; Duan, X. W. Novel synthesized 2,4-DAPG analogues: antifungal activity, mechanism and toxicology. Sci. Rep. 2016, 6, 32266.
[49] Liu, H. X.; Zhang, W. M.; Xu, Z. F.; Chen, Y. C.; Tan, H. B.*; Qiu, S. X.* Isolation, synthesis, and biological activity of tomentosenol A from the leaves of Rhodomyrtus tomentosa. RSC Adv. 2016, 6, 25882-25886.
[50] Liu, H. X.; Chen, K.; Tang, G. H.; Yuan, Y. F.; Tan, H. B.*; Qiu, S. X.* Isolation and biomimetic total synthesis of tomentodiones A-B, terpenoid-conjugated phloroglucinols from the leaves of Rhodomyrtus tomentosa. RSC Adv. 2016, 6, 48231-48236.
[51] Liu, H. X.; Chen, Y. C.; Liu, Y.; Zhang, W. M.; Wu, J. W.; Tan, H. B.*; Qiu, S. X.* Acylphloroglucinols from the fruits leaves of Callistemon viminalis. Fitoterapia 2016, 114, 40-44.
[52] Liu, H. X.; Chen, K.; Yuan, Y.; Xu, Z. F.; Tan, H. B.*; Qiu, S. X.* Rhodomentones A and B, novel meroterpenoids with unique NMR characteristics from Rhodomyrtus tomentosa. Org. Biomol. Chem. 2016, 14, 7354-7360.
[53] Liu, H. X.; Chen, K.; Liu, Y.; Li, C.; Wu, J. W.; Xu, Z. F.; Tan, H. B.*; Qiu, S. X.* Callviminols A-E, new terpenoid-conjugated phloroglucinols from the leaves of Callistemon viminalis. Fitoterapia 2016, 115, 142-147.