魏孝义
研究员/博导
职务：
电话：
020-37252538
地址：
广州市天河区兴科路723号
学历/学位：
博士
电子邮件：
wxy@scbg.ac.cn
邮政编码：
510650
学习工作简历:
1978/10-1982/07 西北师范大学生物系学习，获理学学士学位
1986/09-1989/07 中国科学院昆明植物研究所学习，获理学硕士学位
2003/09-2005/12 华南农业大学学习，获农学博士学位
1982/07-1986/08 西北师范大学植物研究所工作
1989/08-至今 中国科学院华南植物园工作
研究领域：
天然产物化学
承担科研项目情况：
1.国家自然科学基金面上项目，81872773，五种蕨类植物的内生真菌抗MRSA活性代谢产物的研究，2019/01-2022/12，60万元，主持
2.国家自然科学基金面上项目，31470423，抗肿瘤番荔枝内酯维生素偶联物的合成及其受体介导靶向输送作用，2015/01-2018/12，88万元，主持
3.国家自然科学基金面上项目，81172942，鼎湖山真菌抗细菌代谢产物的研究，2012/01-2015/12，62万元，主持
4.国家自然科学基金面上项目，20672114，丝状真菌对荔枝果实致病菌的抗菌物质研究，2007/01-2009/12，28万元，主持
社会任职：
中国植物学会植物资源与植物化学专业委员会委员
广东省药学会中药及天然药物专业委员会副主任委员
广东省药学会药物化学专业委员会副主任委员
广东省药学会制药工程专业委员会常务委员
广东省植物学会理事
获奖及荣誉：
鱼藤酮生物农药产业体系的构建及关键技术集成，国务院，国家科学技术进步奖，二等奖，2010，排名第五（5/10）
国务院政府特殊津贴获得者(2008年)
代表论著：
1.Ping Wu, Hiroyasu Iwahashi, Haihui Xie, Ying Wang, Yanyang Zhou, Akinori Kiso, Yoshihito Kawashima, Xiaoyi Wei*. Star fruit extract and C-glycosylated flavonoid components have potential to prevent air pollutant-induced skin inflammation and premature aging. Natural Products and Bioprospecting, 2022, 12:13.
2.Suying Gao, Ping Wu*, Jinghua Xue, Hanxiang Li, Xiaoyi Wei*. Cytochalasans from the endophytic fungus Diaporthe ueckerae associated with the fern Pteris vittate. Phytochemistry, 2022, 202:113295.
3.Jingfang Shi, Ping Wu, Hanxiang Li, Xiaoyi Wei*, Zihua Jiang*. Synthesis and anticancer activity of Boc-Gly-Pro dipeptide-annonaceous acetogenin prodrugs targeting fibroblast activation protein or other hydrolytic enzymes. Medicinal Chemistry Research, 2022, 31:605-616.
4.Xiaoli Cheng, Hanxiang Li, Juan Chen, Ping Wu, Jinghua Xue, Zhongyu Zhou, Niahe Xia, Xiaoyi Wei*. Bioactive Diarylheptanoids from Alpinia coriandriodora. Natural Products and Bioprospecting, 2021, 11:63–72.
5.Liangxiong Xu, Qiuli Liu, Qingren Zeng*, Ping Wu, Quan Yu, Kongzhen Gu, Jinghua Xue, Xiaoyi Wei*. Radicicol, a novel lead compound against the migratory-stage schistosomula of Schistosoma japonicum. Antimicrobial Agents and Chemotherapy, 2021, 65: e01781–20.
6.Xiaoxia Li, Ping Wu*, Hanxiang Li, JInghua Xue, Hanhong Xu, and Xiaoyi Wei*. Antibacterial and Cytotoxic Phenyltetracenoid Polyketides from Streptomyces morookaense. Journal of Natural Products, 2021, 84:1806–1815.
7.Jingfang Shi, Ping Wu, Xiaoli Chen, Xiaoyi Wei*, Zihua Jiang*. Synthesis and cytotoxic property of annonaceous acetogenin glycoconjugates. Drug Design, Development and Therapy, 2020, 14:4993–5004.
8.Xiaoli Yang, Ping Wu, Jinghua Xue, Hanxiang Li, Xiaoyi Wei*. Cytochalasans from endophytic fungus Diaporthe sp. SC-J0138. Fitoterapia, 2020, 145:104611.
9.Li Yang, Xiaoxia Li, Ping Wu*, Jinghua Xue, Liangxiong Xu, Hanxiang Li, Xiaoyi Wei*. Streptovertimycins A-H, new fasamycin-type antibiotics produced by a soil-derived Streptomyces morookaense. The Journal of Antibiotics, 2020, 73:283–289.
10.Jinghua Xue, Hanxiang Li, Ping Wu, Liangxiong Xu, Yunfei Yuan, Xiaoyi Wei*. Bioactive polyhydroxanthones from Penicillium purpurogenum. Journal of Natural Products, 2020, 83:1480–1487.
11.Mahal Ahmed*, Wu Ping, Jiang Zhihua, Wei Xiaoyi*. Schiff Bases of Tetrahydrocurcumin as Potential Anticancer Agents. Chemistryselect, 2019, 4(1) : 366–369.
12.Li Yang, Hanxiang Li, Ping Wu, Ahmed Mahal, Jinghua Xue, Liangxiong Xu, Xiaoyi Wei*. Dinghupeptins A-D, chymotrypsin inhibitory cyclodepsipeptides produced by a soli-derived streptomyces. Journal of Natural Products, 2018, 81:1928–1936.
13.Liangxiong Xu, Ping Wu, Jinghua Xue, Istvan Molnar, and Xiaoyi Wei*. Antifungal and Cytotoxic β‑Resorcylic Acid Lactones from a Paecilomyces Species. Journal of Natural Products, 2017, 80(8): 2215−2223.
14.Chen Wang, Ping Wu, Xiao-Ling Shen, Xiao-Yi Wei* and Zi-Hua Jiang*. Synthesis, cytotoxic activity and drug combination study of tertiary amine derivatives of 2’,4’-dihydroxyl-6’-methoxyl-3’,5’-dimethylchalcone. RSC Adv., 2017, 7: 48031−48038.
15.Chen Wang, Ping Wu, Shuai Tian, Jinghua Xue, Liangxiong Xu, Hanxiang Li, and Xiaoyi Wei*. Bioactive Pentacyclic Triterpenoids from the Leaves of Cleistocalyx operculatus. Journal of Natural Products, 2016, 79: 2912−2923.
16.Ping Wu, Jinghua Xue, Lei Yao, Liangxiong Xu, Hanxiang Li, Xiaoyi Wei*. Bisacremines E-G, Three Polycyclic Dimeric Acremines Produced by Acremonium persicinum SC0105. Organic Letters, 2015, 17(19): 4922–4925.
17.Ping Wu, Lei Yao, Liangxiong Xu, Jinghua Xue, Xiaoyi Wei*. Bisacremines A-D, Dimeric Acremines Produced by a Soil-Derived Acremonium persicinum Strain. Journal of Natural Products, 2015, 78(9): 2161–2166.
18.Liangxiong Xu, Ping Wu, Stephen J. Wright, Liangcheng Du*, and Xiaoyi Wei*. Bioactive Polycyclic Tetramate Macrolactams from Lysobacter enzymogenesand Their Absolute Configurations by Theoretical ECD Calculations. Journal of Natural Products, 2015, 78: 1841−1847.
19.Wang Chen, Wu Ping, Shi Jing-Fang, Jiang Zi-Hua*, Wei Xiao-Yi*. Synthesis and cancer cell growth inhibitory activity of icaritin derivatives. European Journal of Medicinal Chemistry, 2015, 100, 139–150.
20.Jinghua Xue#, Ping Wu#, Liangxiong Xu, Xiaoyi Wei*. Penicillitone, a Potent in Vitro Anti-inflammatory and Cytotoxic Rearranged Sterol with an Unusual Tetracycle Core Produced by Penicillium purpurogenum. Organic Letters, 2014, 16(5):1518–1521.
21.Ying Fu, Ping Wu, Jinghua Xue, Xiaoyi Wei*. Cytotoxic and Antibacterial Quinone Sesquiterpenes from a Myrothecium Fungus. Journal of Natural Products, 2014, 77(8): 1791–1799.
22.Liangxiong Xu, Jinghua Xue, Ping Wu, Xiaoying You, Xiaoyi Wei*. Absolute configurations of four resorcylic acid lactones, paecilomycins J-M, CD/TDDFT calculations. Chirality, 2014, 26: 44–50.
23.Ping Wu, Min Wu, Liangxiong Xu, Haihui Xie, Xiaoyi Wei*. Anti-inflammatory cyclopeptides from exocarps of sugar-apples. Food Chemistry, 2014, 152: 23–28.
24.Jingfang Shi, Ping Wu, Zihua Jiang*, Xiaoyi Wei*. Synthesis and tumor cell growth inhibitory activity of biotinylated annonaceous acetogenins. European Journal of Medicinal Chemistry, 2014,71: 219–228.
25.Liangxiong Xu, Ping Wu, Huanhuan Wei, Jinghua Xue, Xiaopeng Hu, Xiaoyi Wei*. Paecilomycins J–M, four new b-resorcylic acid lactones from Paecilomyces sp. SC0924. Tetrahedron Letters, 2013, 54: 2648–2650.
26.Wenbin Ding, Zihua Jiang, PingWu, Liangxiong Xu, Xiaoyi Wei*. Resin glycosides from the aerial parts of Operculina turpethum. Phytochemistry, 2012, 81: 165–174.
27.Wenbing Ding, Fanli Zeng, Liangxiong Xu, Yunyun Chen, Yifei Wang, and Xiaoyi Wei*. Bioactive Dammarane-Type Saponins from Operculina turpethum. Journal of Natural Products, 2011, 74: 1868–1874.
28.Min Wu, Ping Wu, Haihui Xie, Guojiang Wu, Xiaoyi Wei*. Monoterpenoid Indole Alkaloids Mediating DNA Strand Scission from Turpinia arguta. Planta Medica, 2011, 77: 284–286.
29.Liangxiong Xu, Zhengxiang He, Jinghua Xue, Xiaoping Chen, Xiaoyi Wei*. b-Resorcylic acid lactones from a Paecilomyces Fungus. Journal of Natural Products, 2010, 73 (5): 885–889.
30.Ping Wu, Haihui Xie, Wenqin Tao, Shenyu Niu, Xiaoyi Wei*. Phytoecdysteroids from the rhizomes of Brainea insignis. Phytochemistry, 2010, 71: 975–981.