As sessile organisms, plants encounter numerals biotic- and abiotic-stresses during their life span. Plants have evolved a rapid and efficient signal transduction network, and produced small active molecules in response to the inner and outer environmental cues for surviving. Using Arabidopsis and South China characteristic cash-crop/resource-plant as models, research of the lab focus on: 1) Plant-microbe interaction, we focus on the molecular mechanisms of protein posttranslational modifications, esp. Ubiquitination, and histone modification in the regulation of plant and virus interaction. 2) Signal transduction of plant responses to the combination of biotic and abiotic stresses. 3) Metabolic regulatory network of small bioactive secondary molecules esp. the natural pigment such as Anthocyanin and Carotenoids in flowers and fruits.